![ORY-1001 (RG-6016) - LSD1 Inhibitor. CAS# 1431326-61-2 430 3-d]pyrimidin-2-yl)methyl)acetamide](https://cdn.shopify.com/s/files/1/0389/1897/9723/products/xcessbio1453992064.5485138.png?v=1742656451)
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3-d]pyrimidin-2-yl)methyl)acetamide
The inhibition of mutant IDH2 and its neoactivity is therefore a potential therapeutic treatment for cancer
Preclinical Development of ARRY-162
Formula: C11H14N4S
Smiles: CC(C1CCN(CC1)S(=O)(=O)CC)N1C2=CC=CC=C2C(C(=O)NCC2=C(C=C(C)NC2=O)OC)=C1C
ORY-1001 (RG-6016) - LSD1 Inhibitor. CAS# 1431326-61-2 430 3-d]pyrimidin-2-yl)methyl)acetamideORY 1001, CAS No. 1431326 61 2, is a highly potent and selective inhibitor of Lysine Specific Demethylase 1 (LSD1) with IC50 <20 nM. It is highly selective over related enzymes such as MAO A B. ORY 1001 affects AML stem cells, a sub population of cancer cells that has been proposed to be responsible for frequent relapses of the disease. It significantly reduces tumor cell load and increases survival time in mouse models of Acute Lymphoblastic
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